literatura

• Gigantic business: titin properties and function through thick and thin
  Linke WA, Hamdani N. Circ Res. 2014 Mar 14;114(6):1052-68. doi: 10.1161/CIRCRESAHA.114.301286. PMID: 24625729.


• Cardiomyopathies and Genetic Testing in Heart Failure: Role in Defining Phenotype-Targeted Approaches and Management
  Yogasundaram H, Alhumaid W, Dzwiniel T, Christian S, Oudit GY. Can J Cardiol. 2021 Apr;37(4):547-559. doi: 10.1016/j.cjca.2021.01.016. Epub 2021 Jan 22. PMID: 33493662.


• Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D
  Herwig M, Kolijn D, at al. Front Physiol. 2020 Apr 15;11:240. doi: 10.3389/fphys.2020.00240. PMID: 32351396; PMCID: PMC7174613.


• Sildenafil and B-Type Natriuretic Peptide Acutely Phosphorylate Titin and Improve Diastolic Distensibility In Vivo
  Bishu K, Hamdani N, at al. Circulation. 2011 Dec 20;124(25):2882-91. doi: 10.1161/CIRCULATIONAHA.111.048520. Epub 2011 Dec 5. PMID: 22144574; PMCID: PMC3412357.


• Nicotinamide for the treatment of heart failure with preserved ejection fraction
  Abdellatif M, Trummer-Herbst V, at al. Sci Transl Med. 2021 Feb 10;13(580):eabd7064. doi: 10.1126/scitranslmed.abd7064. PMID: 33568522; PMCID: PMC7611499.


• Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)
  de Boer RA, Heymans S, et al . Eur J Heart Fail. 2022 Mar;24(3):406-420. doi: 10.1002/ejhf.2414. Epub 2022 Jan 14. PMID: 34969177; PMCID: PMC9305112.


• Acetylation and phosphorylation changes to cardiac proteins in experimental HFpEF due to metabolic risk reveal targets for treatment
  Koser F, Hobbach AJ, at al . Life Sci. 2022 Nov 15;309:120998. doi: 10.1016/j.lfs.2022.120998. Epub 2022 Sep 27. PMID: 36179815.


• Heart failure with preserved ejection fractionin perspective
  Pfeffer MA, Shah AM, Borlaug BA. Circ Res. 2019 May 24;124(11):1598-1617. doi: 10.1161/CIRCRESAHA.119.313572. PMID: 31120821; PMCID: PMC6534165.


• Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle
  Li Y, Hessel AL, at al . Elife. 2020 Dec 24;9:e64107. doi: 10.7554/eLife.64107. PMID: 33357376; PMCID: PMC7781594.


• Titin force in muscle cells alters lattice order, thick and thin filament protein formation
  Hessel AL, Ma W, at al . Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2209441119. doi: 10.1073/pnas.2209441119. Epub 2022 Nov 21. PMID: 36409887; PMCID: PMC9860331.


• A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues
  Rivas-Pardo JA, Li Y, at al. Nat Commun. 2020 Apr 28;11(1):2060. doi: 10.1038/s41467-020-15465-9. PMID: 32345978; PMCID: PMC7189229.


• Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice
  Rudolph F, Fink C, at al . Nat Commun. 2020 Jun 19;11(1):3133. doi: 10.1038/s41467-020-16929-8. PMID: 32561764; PMCID: PMC7305127.


• Posttranslational modifications of titin from cardiac muscle: how, where, and what for?
  Koser F, Loescher C, Linke WA. FEBS J. 2019 Jun;286(12):2240-2260. doi: 10.1111/febs.14854. Epub 2019 Apr 29. PMID: 30989819; PMCID: PMC6850032.


• Titin (TTN): from molecule to modifications, mechanics, and medical significance
  Loescher CM, Hobbach AJ, Linke WA. Cardiovasc Res. 2022 Nov 10;118(14):2903-2918. doi: 10.1093/cvr/cvab328. PMID: 34662387; PMCID: PMC9648829.


• Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx)
  Loescher CM, Breitkreuz M, at al. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24545-24556. doi: 10.1073/pnas.2004900117. Epub 2020 Sep 14. PMID: 32929035; PMCID: PMC7533878.


• S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding
  Alegre-Cebollada J, Kosuri P, at al Cell. 2014 Mar 13;156(6):1235-1246. doi: 10.1016/j.cell.2014.01.056. PMID: 24630725; PMCID: PMC3989842.


• Reverse engineering of the giant muscle protein titin
  Li H, Linke WA, et al Nature. 2002 Aug 29;418(6901):998-1002. doi: 10.1038/nature00938. PMID: 12198551.


• I-Band-Titin-in-Cardiac-Muscle-Is-a-Three-Element Molecular Spring and Is Critical for Maintaining Thin Filament Structure
  Linke WA, Rudy DE, et al J Cell Biol. 1999 Aug 9;146(3):631-44. doi: 10.1083/jcb.146.3.631. PMID: 10444071; PMCID: PMC2150553.


• Nature of PEVK-titin elasticity in skeletal muscle
  Linke WA, Ivemeyer M, Mundel P, Stockmeier MR, Kolmerer B. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8052-7. doi: 10.1073/pnas.95.14.8052. PMID: 9653138; PMCID: PMC20927.


• Titin Gene and Protein Functions in Passive and Active Muscle
  Linke WA. Annu Rev Physiol. 2018 Feb 10;80:389-411. doi: 10.1146/annurev-physiol-021317-121234. Epub 2017 Nov 13. PMID: 29131758.


• Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations
  Fomin A, Gärtner A, et al. Sci Transl Med. 2021 Nov 3;13(618):eabd3079. doi: 10.1126/scitranslmed.abd3079. Epub 2021 Nov 3. PMID: 34731013.


• Genetic Basis and Genotype–Phenotype Correlations in Han Chinese Patients with Idiopathic Dilated Cardiomyopathy
  Zhang XL, Xie J, Lan RF, Kang LN, Wang L, Xu W, Xu B. Sci Rep. 2020 Feb 10;10(1):2226. doi: 10.1038/s41598-020-58984-7. PMID: 32041989; PMCID: PMC7010767.


• Titin: roles in cardiac function and diseases
  Stroik D, Gregorich ZR, Raza F, Ge Y, Guo W. Front Physiol. 2024 Apr 10;15:1385821. doi: 10.3389/fphys.2024.1385821. PMID: 38660537; PMCID: PMC11040099.


• Exploring TTN variants as genetic insights into cardiomyopathy pathogenesis and potential emerging clues to molecular mechanisms in cardiomyopathies
  Jolfayi AG, Kohansal E, Ghasemi S, et al. 2024 Mar 4;14(1):5313. doi: 10.1038/s41598-024-56154-7. PMID: 38438525; PMCID: PMC10912352.


• Titin's cardiac-specific N2B element is critical to mechanotransduction during volume overload of the heart
  Strom J, Bull M, Gohlke J, et al. J Mol Cell Cardiol. 2024 Jun;191:40-49. doi: 10.1016/j.yjmcc.2024.04.006. Epub 2024 Apr 10. PMID: 38604403; PMCID: PMC11229416.


• An isoform of the giant protein titin is a master regulator of human T lymphocyte trafficking
  Toffali L, D'Ulivo B, Giagulli C, et al. Cell Rep. 2023 May 30;42(5):112516. doi: 10.1016/j.celrep.2023.112516. Epub 2023 May 18. PMID: 37204926.


• The Giant Protein Titin’s Role in Cardiomyopathy: Genetic, Transcriptional, and Post-translational Modifications of TTN and Their Contribution to Cardiac Disease
  Tharp CA, Haywood ME, Sbaizero O, et al. Front Physiol. 2019 Nov 28;10:1436. doi: 10.3389/fphys.2019.01436. PMID: 31849696; PMCID: PMC6892752.


• Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function
  Zaunbrecher RJ, Abel AN, Beussman K, et al. Circulation. 2019 Nov 12;140(20):1647-1660. doi: 10.1161/CIRCULATIONAHA.119.039521. PMID: 31587567; PMCID: PMC6911360.


• A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies
  Gigli M, Begay RL, Morea G, et al. Front Cardiovasc Med. 2016 Jul 21;3:21. doi: 10.3389/fcvm.2016.00021. PMID: 27493940; PMCID: PMC4954824.